Polycystic Ovary Syndrome (PCOS)

IR Symptoms and GTT?

Question:

Hi… Well the fourth round of clomid (this time 150 mg + hCG shot) did not work.  My doc has agreed to test me for IR and refer me to a RE. First, what are the symptoms of IR?  I have read the classics e.g. pco, hirsutism, difficulty with weight loss… but I have also seen others in this ng refer to *hypoglycemic*-like symptoms and overactive bladder… so does anyone have a definitive list? Second… the test they have scheduled me for tomorrow is to fast tonight, then in the morning they will do blood draw to measure glucose and insulin levels after fasting.  But the way I understand the situation, one needs to actually do a GTT where then after fasting, oral glucose is administered to turn on insulin, and then at several time points over the next 3 hours they draw again to measure whether glucose is being taken up and insulin is being turned off. So do I misunderstand the required test, or is it possible that the doc is not planning the correct test?  Will IR manifest itself if one only does one blood draw after fasting? Thanks tons… P- 35 yr. old primary 1 year 4 cycles CC

Response:

Just a friendly reminder that one should not crosspost to alt.infertility.primary. In alt.infertility.primary P- <scarb…@niehs.nih.gov> wrote: > First, what are the symptoms of IR?  I have read the classics > e.g. pco, hirsutism, difficulty with weight loss… but I > have also seen others in this ng refer to *hypoglycemic*-like > symptoms and overactive bladder… so does anyone have a > definitive list?

IR and PCO are related but not the same.  14 years ago I tested as hypoglycemic in a GTT test.  Two years ago, they discovered the IR.  Low carb and Rezulin are currently working their collective magic.  I don’t have a definitive list of any of my myriad diseases.  If they came up with one, I would want to see it first.  :-) > Second… the test they have scheduled me for tomorrow is to > fast tonight, then in the morning they will do blood draw to > measure glucose and insulin levels after fasting.  But the > way I understand the situation, one needs to actually do > a GTT where then after fasting, oral glucose is administered > to turn on insulin, and then at several time points over > the next 3 hours they draw again to measure whether glucose > is being taken up and insulin is being turned off.

A GTT will not determine insulin levels.  Fasting C-peptide will give them your glucose and your insulin levels.  I wouldn’t wish a GTT on my worst enemy.  I passed out from my first and last one. > So do I misunderstand the required test, or is it possible that > the doc is not planning the correct test?  Will IR manifest itself > if one only does one blood draw after fasting?

I think he is right on track.  He did what my doctor did. Louise

Response:

> your glucose and your insulin levels.  I wouldn’t wish a GTT on my worst > enemy.  I passed out from my first and last one.

I’m sorry you had such a bad experience, Louise, but I honestly think you’re the exception, not the rule!  I felt a bit lightheaded, but was able to lie down during the test.  At half-hour intervals a nurse would come in and painlessly draw a vial of blood.  Before leaving the lab, I had a snack and then the lightheadedness went away.  (BTW,  I did test very glucose impaired, and my endo put me on Metformin as a result.) Claudia

Response:

Filed under: PCO

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