Metaformin for PCOD??
Question:
has anyone heard of this new drug Metaformin to help people with polycystic ovarian disease become pregnant? If anyone has please post or email me, until then I will wait for my fertility doctor to call me. I have been trying for 6 years and still no pregnancies. We were able to get some eggs but never got pregnant. Hopefully this will be the answer for me. Thanks
Response:
The first time on metformin I became pregnant. I also did 150mg clomid cd5-9 and 2 amp fertinex cd 10-16. I produced at least 3 great follicles on the day of hcg shot. Who knows how many matured and ovulated 36 hours later. I felt like a chicken must when she is laying her eggsLOL.I think the metformin helped my ovaries to respond to the fertility drugs better. once I got pregnant I stopped the metformin but MC 2 week later=( .I will probably start the metformin very soon again so my body ought to be good and ready to get pregnant again and for keeps the begining of the new year.The metformin helps regulate the insulin levels in you body .The insulin levels have something to do with cysts on the ovaries.I really haven’t looked into it that much ,alls I know is I conceived a precious angel while using it and I also have pco.Good luck to you. you will be in my thoughts and prayers. KIM ^^< ” =0= ~~ 0ne angel 11-2-98 ^i^
Response:
<<has anyone heard of this new drug Metaformin to help people with polycystic ovarian disease become pregnant? Metformin (glucophage) is an old drug, with a new use. It is commonly used to control Type II diabetes, but has been found to help with PCOS (which is thought to be caused by insulin resistance). To learn more about Metformin’s use with PCOS, try this website…it’s very interesting and should help. http://www.uc.edu/~gartsips/Index.htm#topics Click on the PCOS link when you get there. -K
Response:
Metformin is very helpful for PCOS women that have the insulin resistance component (high blood glucose levels) and this is easily and cheaply tested with a Dr ordered lab test for a fasting 2 hour Glucose Tolerance Test. My RE has seen positive results when patients do have insulin resistance, but that it does not help if you have no blood sugar problems. Here’s the link to the New England Journal of Medicine, where you can order the full study text. http://www.nejm.org/content/1998/0338/0026/1876.asp Regards, Kaitlyn I HATE Metformin, but am taking it!
Response:
has anyone heard of this new drug Metaformin to help people with polycystic ovarian disease become pregnant?
I am on metformin and i have been for a month and am diagnosed as PCO and high insulin. I ovulated without fertility drugs!! I just found out yesterday!! Supposedly in PCO’ers lowering the insulin suppresses the androgens around the ovary which in turn causes ovulation if that doesnt work, they can pair it with fertility drugs and you will respond better. Have your dr do a fasting insulin and glucose test and go from there. Feel free to ask me any more questions Love shelley
Response:
I am pregnant (at 37) after taking Metformin for three months, losing 37 pounds on Richard Simmons Deal-a-Meal (I am now 250, was 287!) and then having a stimulated cycle (Gonal- f, HCG, IUI, Crinone). I had been TTC for 4 years. I totally credit the Metformin with enabling me to become pregnant: I had done THREE IVFs prior to this(48 useless eggs on one of the tries!) plus two frozen cycles: none ever worked. The embryos appeared to be perfect every time — 9 and 10 cells (well, the previously frozen ones were 5 – 7). My doctor explained something to me about how, prior to Metformin, the eggs had been maturing in follicles which were providing an inhospitable hormonal environment and, thus, despite the good appearance (I had implantation 4 times but they were chemical pregnancy), they never really had a chance because they were not "Good Eggs." Go for it, girl! Metformin worked for me! I can’t even believe it’s me this time…Metformin is a miracle!
Response:
I am on metformin and i have been for a month and am diagnosed as PCO and high insulin. I ovulated without fertility drugs!! I just found out yesterday!!
What dose of metformin were you on? How long had you been on the full dose? I’m on 1500mg a day, but have only been on the full dose for about 2.5 weeks. I’m taking provera right now and then on day 21 of next cycle RE will start checking progesterone level for ovulation. My RE didn’t give me any test to see if I was insulin resistant. He said even if I wasn’t, it would make me respond better to fertility drugs. I just hope I ovulate without one fertility drug. I’m sick of shots, IUI’s and only having sex when it’s allowed. I’m sorry for rambling, I just thought I could get some encouragement from your story. Thanks! Nicole Blythe
Response:
<<Metformin is very helpful for PCOS women that have the insulin resistance component (high blood glucose levels) Actually, you can be insulin resistant and have normal blood glucose levels. With PCOS, the concern is with elevated *insulin* levels. The glucose tolerance test is a good indicator, but 2-hr insulin levels must be measured at the same time. High glucose levels can indicate type II diabetes (w/insulin resistance), which is also treated w/metformin.
Response:
What dose of metformin were you on?
I was at 2000 now i went back down to 1000 and will go up to 1500 next week. The 2000 made me very sick. How long had you been on the full dose?
I slowly worked my way up….every week i went up 500 mg. I have been on met for about a month and a half. The weird thing is I was waiting for af to come and during that time span i ovulated a second time without af even showing. strange!! RE didn’t give me any test to see if I was insulin resistant. He said even if I wasn’t, it would make me respond better to fertility drugs.
insulin resistance and treating that helps the PCO symptoms. That concerns me that he prescribed it without checking your levels. But yes if you are IR it will definetely either cause ovulation or paired with fertility drugs you will be a better responder. Have your dr. check your levels, metformin has some pretty nasty side effects. and I know how you feel about all shots and planning sex, but hopefully metformin will be your wonder drug! God Bless you, shelley
Response:
Hello. My name is Carol. I was recently diagnosed with PCO also. My doctor started me on BC pills for about two months then switched me to glucophage for the past month even though I was not insulin resistant. After about 2 weeks I had a menstral cycle. I just had my levels of testosterone and LH levels checked today hopefully they will be lower. My doctor says that glucphage will work whether or not you are actually insulin resistant. Please let me know if you have new, and good luck to you all. Carol
Response:
congrats. !!!!! That is such good news. I just started on metformin about 45days also. Please keep me informed on how everyting is going Carol
Response:
Filed under: Polycystic Ovarian Disease
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