clomiphine, igf-1 and pcos
Question:
My son, now 6 months old, was concieved on 150 mg of clomiphene. In addition, my first pregnancy, which miscarried early on, was achieved on 100 mg of clomiphene. This put me up to a grand total of 10 months total of clomophene, but I had no reactions. So I know that it does work for some women, but have heard that not all PCOS women can get pregnant on Clomid (the brand name). Carrie — Cleverly Disguised As A Responsible Adult rie…@miribiledictu.net http://www.miribiledictu.net Sent via Deja.com http://www.deja.com/ Before you buy.
Response:
>i was on clomiphene for 6 months, way past the 3 month recommendation.
I was on Clomid for 3 years with no adverse reactions. I went off when finally getting pregnant with my now 10 year old daughter.
Response:
i was on clomiphene for 6 months, way past the 3 month recommendation. i did finally ovulate one night. i got terrible middlescmertz (ovulatory pain)one night when i was out to dinner.the only time ever in my life that i felt it. i had a baby nine months later. the second round 2 years later i started breaking out in welts head to toe. i tried everything to make it work, my re put me on a steroid even to keep the allergic reaction down. but each dose the reaction got worse and i had to go to injectables instead. kooky. barb In article <8u13nm$ag…@nnrp1.deja.com>, wuzzy <wu…@my-deja.com> wrote: – Hide quoted text — Show quoted text -> Clomiphine is apparently the most commonly prescribed drug for > inducing ovulation in PCOS… > anyway, new studies seem to suggest that it does this despite no > alterations in insulin resistance… the suggested mechanism is that it > reduces IGF-1 (a GH-related hormone that increases androgens) > anyway, thats from this month’s human reproduction: > has anyone tried clomiphine with success? I’m curious as to whether it > affects androgen levels even though it doesn’t affect Insulin > resistance.. > 1: Hum Reprod 2000 Nov;15(11):2302-2305 > Related > Articles, Books, LinkOut > Clomiphene citrate increases insulin-like growth > factor binding > protein-1 and reduces insulin-like growth > factor-I without > correcting insulin resistance associated with > polycystic ovarian > syndrome. > De Leo V, la Marca A, Morgante G, Ciotta L, > Mencaglia L, Cianci A, Petraglia > F > Department Obstetrics and Gynecology, University > of Study of Siena, > Department Obstetrics and Gynecology, University > of Study of Catania and > Centro Florence, Firenze, Italy. > [Record supplied by publisher] > The induction of ovulation by clomiphene could be > the result of interaction of > the drug at various levels: hypothalamus, > pituitary and ovary. It was > demonstrated that administration of clomiphene to > women with polycystic > ovarian syndrome (PCOS) is accompanied by a > reduction in plasma > concentrations of insulin-like growth factor-I > (IGF-I). IGF-I seems to have an > overall negative effect on normal > folliculogenesis and ovulation. The aim of the > present study was to evaluate the effect of > clomiphene on plasma > concentrations of IGF-I and IGF binding protein > (IGFBP)-1 and on insulin > resistance associated with PCOS. Fifteen patients > diagnosed with PCOS were > recruited. Clinical diagnosis was based on > chronic oligomenorrhoea or > amenorrhoea and hyperandrogenaemia. Clomiphene > citrate was administered at > a dose of 100mg/day to all women from day 5 to > day 9 of the spontaneous or > medroxyprogesterone acetate (MAP)-induced > menstrual cycle. Blood sampling > and a 2 h oral glucose loading test (75 g) were > performed the day before and > after the course of clomiphene. Ovulation was > confirmed in 13/15 PCOS > patients. Plasma concentrations of IGF-I > decreased by 31.5% (434 +/- 84 versus > 297 +/- 71 ng/ml; P: < 0.05) after 5 days of > clomiphene therapy, whereas plasma > concentrations of IGFBP-1 increased by > approximately 28.1% (26.3 +/- 4 versus > 36.6 +/- 7 ng/ml; P: < 0.05). This gave a 56.5% > reduction in the IGF-I:IGFBP-1 > ratio (21.9 versus 9.53). No significant changes > in basal plasma concentrations > of fasting insulin or area under the insulin > curve were observed in response to > oral loading. The present results show that > clomiphene does not cause changes > in insulin resistance associated with PCOS but > reduces plasma concentrations > of IGF-I and increases those of IGFBP-1, with a > consequent marked reduction in > the IGF-I:IGFBP-1 ratio. > Sent via Deja.com http://www.deja.com/ > Before you buy.
Sent via Deja.com http://www.deja.com/ Before you buy.
Response:
My dh and I were successful on one round of Clomiphene, or Clomid as it is commonly know. We now are proud parents of son, Evan Matthew, born 07/27/00. However, alot of women with PCOS do not respond to clomid. Shannon In article <8u13nm$ag…@nnrp1.deja.com>, wuzzy <wu…@my-deja.com> wrote: – Hide quoted text — Show quoted text -> Clomiphine is apparently the most commonly prescribed drug for > inducing ovulation in PCOS… > anyway, new studies seem to suggest that it does this despite no > alterations in insulin resistance… the suggested mechanism is that it > reduces IGF-1 (a GH-related hormone that increases androgens) > anyway, thats from this month’s human reproduction: > has anyone tried clomiphine with success? I’m curious as to whether it > affects androgen levels even though it doesn’t affect Insulin > resistance.. > 1: Hum Reprod 2000 Nov;15(11):2302-2305 > Related > Articles, Books, LinkOut > Clomiphene citrate increases insulin-like growth > factor binding > protein-1 and reduces insulin-like growth > factor-I without > correcting insulin resistance associated with > polycystic ovarian > syndrome. > De Leo V, la Marca A, Morgante G, Ciotta L, > Mencaglia L, Cianci A, Petraglia > F > Department Obstetrics and Gynecology, University > of Study of Siena, > Department Obstetrics and Gynecology, University > of Study of Catania and > Centro Florence, Firenze, Italy. > [Record supplied by publisher] > The induction of ovulation by clomiphene could be > the result of interaction of > the drug at various levels: hypothalamus, > pituitary and ovary. It was > demonstrated that administration of clomiphene to > women with polycystic > ovarian syndrome (PCOS) is accompanied by a > reduction in plasma > concentrations of insulin-like growth factor-I > (IGF-I). IGF-I seems to have an > overall negative effect on normal > folliculogenesis and ovulation. The aim of the > present study was to evaluate the effect of > clomiphene on plasma > concentrations of IGF-I and IGF binding protein > (IGFBP)-1 and on insulin > resistance associated with PCOS. Fifteen patients > diagnosed with PCOS were > recruited. Clinical diagnosis was based on > chronic oligomenorrhoea or > amenorrhoea and hyperandrogenaemia. Clomiphene > citrate was administered at > a dose of 100mg/day to all women from day 5 to > day 9 of the spontaneous or > medroxyprogesterone acetate (MAP)-induced > menstrual cycle. Blood sampling > and a 2 h oral glucose loading test (75 g) were > performed the day before and > after the course of clomiphene. Ovulation was > confirmed in 13/15 PCOS > patients. Plasma concentrations of IGF-I > decreased by 31.5% (434 +/- 84 versus > 297 +/- 71 ng/ml; P: < 0.05) after 5 days of > clomiphene therapy, whereas plasma > concentrations of IGFBP-1 increased by > approximately 28.1% (26.3 +/- 4 versus > 36.6 +/- 7 ng/ml; P: < 0.05). This gave a 56.5% > reduction in the IGF-I:IGFBP-1 > ratio (21.9 versus 9.53). No significant changes > in basal plasma concentrations > of fasting insulin or area under the insulin > curve were observed in response to > oral loading. The present results show that > clomiphene does not cause changes > in insulin resistance associated with PCOS but > reduces plasma concentrations > of IGF-I and increases those of IGFBP-1, with a > consequent marked reduction in > the IGF-I:IGFBP-1 ratio. > Sent via Deja.com http://www.deja.com/ > Before you buy.
– Shannon First-time Mommy to Evan 07/27/00 PCOS diagnosed 1989 Rezulin / Clomid Sent via Deja.com http://www.deja.com/ Before you buy.
Response:
Clomiphine is apparently the most commonly prescribed drug for inducing ovulation in PCOS… anyway, new studies seem to suggest that it does this despite no alterations in insulin resistance… the suggested mechanism is that it reduces IGF-1 (a GH-related hormone that increases androgens) anyway, thats from this month’s human reproduction: has anyone tried clomiphine with success? I’m curious as to whether it affects androgen levels even though it doesn’t affect Insulin resistance.. 1: Hum Reprod 2000 Nov;15(11):2302-2305 Related Articles, Books, LinkOut Clomiphene citrate increases insulin-like growth factor binding protein-1 and reduces insulin-like growth factor-I without correcting insulin resistance associated with polycystic ovarian syndrome. De Leo V, la Marca A, Morgante G, Ciotta L, Mencaglia L, Cianci A, Petraglia F Department Obstetrics and Gynecology, University of Study of Siena, Department Obstetrics and Gynecology, University of Study of Catania and Centro Florence, Firenze, Italy. [Record supplied by publisher] The induction of ovulation by clomiphene could be the result of interaction of the drug at various levels: hypothalamus, pituitary and ovary. It was demonstrated that administration of clomiphene to women with polycystic ovarian syndrome (PCOS) is accompanied by a reduction in plasma concentrations of insulin-like growth factor-I (IGF-I). IGF-I seems to have an overall negative effect on normal folliculogenesis and ovulation. The aim of the present study was to evaluate the effect of clomiphene on plasma concentrations of IGF-I and IGF binding protein (IGFBP)-1 and on insulin resistance associated with PCOS. Fifteen patients diagnosed with PCOS were recruited. Clinical diagnosis was based on chronic oligomenorrhoea or amenorrhoea and hyperandrogenaemia. Clomiphene citrate was administered at a dose of 100mg/day to all women from day 5 to day 9 of the spontaneous or medroxyprogesterone acetate (MAP)-induced menstrual cycle. Blood sampling and a 2 h oral glucose loading test (75 g) were performed the day before and after the course of clomiphene. Ovulation was confirmed in 13/15 PCOS patients. Plasma concentrations of IGF-I decreased by 31.5% (434 +/- 84 versus 297 +/- 71 ng/ml; P: < 0.05) after 5 days of clomiphene therapy, whereas plasma concentrations of IGFBP-1 increased by approximately 28.1% (26.3 +/- 4 versus 36.6 +/- 7 ng/ml; P: < 0.05). This gave a 56.5% reduction in the IGF-I:IGFBP-1 ratio (21.9 versus 9.53). No significant changes in basal plasma concentrations of fasting insulin or area under the insulin curve were observed in response to oral loading. The present results show that clomiphene does not cause changes in insulin resistance associated with PCOS but reduces plasma concentrations of IGF-I and increases those of IGFBP-1, with a consequent marked reduction in the IGF-I:IGFBP-1 ratio. Sent via Deja.com http://www.deja.com/ Before you buy.
Response:
Filed under: Polycystic Ovarian
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