Polycystic Ovary Syndrome (PCOS)

Polycystic Ovary Disease/Clomiphene

Question:

Clomid is the most common fertility drug given to women with PCOS.  It’s a toss-up as to if she’s going to ovulate on it, but I have to warn you that even if she does, there are no guarantees she’ll get pregnant.  But then, she just might. The big thing to know [and it's almost always brushed off by drs] is that in a certain percentage of women, the higher doses can cause the mucous to become hostile…the pH is off and it kills sperm…and then eventually dries up all together.  They can get around that with IUI…insemination. She must chart her temp every morning, and make sure she demands a day 21 progesterone draw to verify that she ovulated.  Also, she must have ultrasounds done to make sure she has no cysts [of 1-2 very tiny ones] before starting each cycle, otherwise she’ll have to sit that cycle out. m ——————————————————- In the beginning there was the Word.     And the Word was Chocolate.       And it was good…        Confections, 1.5 ounces, 240 calories.

Response:

<<……..in a certain percentage of women, the higher doses [of clomid] can cause the mucous to become hostile…the pH is off and it kills sperm…and then eventually dries up all together.  They can get around that with IUI…insemination…>> Yes, clomid works by blocking estrogen, in turn stimulating GnRH, which causes LH and FSH to rise, inducing ovulation.  Estrogen is repsonsible for fertile mucus and uterine lining.  When estrogen is blocked, (like by using clomid), mucus can dry up and become thick, immobilizing sperm.  However, even if you have an IUI, clomid can also render the uterine lining to be so thin, that should fertilization occur, implantation of the embryo may be impossible.  Been there……

Response:

Filed under: Polycystic Ovary Disease

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